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KMID : 0361020160590040287
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Korean Journal of Otolaryngology - Head and Neck Surgery
2016 Volume.59 No. 4 p.287 ~ p.292
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Chronic Obstructive Pulmonary Disease Is Negatively Related with Nasal Polyp in Middle Aged and Elderly Chronic Rhinosinusitis Patients
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Lee Min-Gu
Kim Si-Whan
Yang Jeong-Hwan
Lee Ju-Han
Choi Hyo-Geun
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Abstract
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Background and Objectives: Chronic obstructive pulmonary disease (COPD) is known to induce chronic rhinosinusitis (CRS). Nasal polyp, which is frequently found in patients with CRS, seems to have close relationship with COPD, but little is known about its relationship with COPD. In this study, we investigated the relationship between COPD and nasal polyp in middle aged and elderly CRS patients.
Subjects and Method: We analyzed the clinical data of 174 patients (age of over 50 years) with CRS. Patients were divided as COPD [forced expiratory volume (FEV1)/forced vital capacity (FVC)<70%, n=30] and non-COPD group (FEV1/FVC≥70%, n=144) according to the pulmonary function test results. Binary logistic regression analysis was used to describe the relationships between clinically relevant factors related to nasal polyp.
Results: On logistic regression analysis, no significant relationship was found between age [adjusted odds ratio (AOR): 1.058, 95% confidence interval for the difference (CI)=0.995-1.126, p=0.073], sex AOR: 0.897, 95% CI=0.366-2.415, p=0.897), smoking (AOR: 0.434, 95% CI=0.154-1.219, p=0.113) and obesity (underweight AOR: 3.833, 95% CI=0.781-18.808, p=0.098, overweight AOR: 5.169, 95% CI=0.996-26.814, p=0.051, obese AOR: 2.911, 95% CI=0.335-25.329, p=0.333) with polyp. However, there was a negative correlation between COPD history and nasal polyp with statistical significance (AOR: 0.288, 95% CI=0.102-0.809, p=0.018).
Conclusion: Our findings suggest that patients with COPD are less likely to have nasal polyp than patients without COPD.
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KEYWORD
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Aged, Chronic obstructive pulmonary disease, Middle aged, Nasal polyps, Sinusitis
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